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Alternative Names Return to topPickwickian syndrome
Definition Return to top
Obesity hypoventilation syndrome (OHS) is a condition that occurs in obese people, in which poor breathing leads to lower oxygen levels and higher carbon dioxide levels in the blood.
Causes Return to top
The exact cause of OHS in unknown. Most (but not all) patients with the syndrome have a form of sleep apnea.
OHS is believed to result from both a defect in the brain's control over breathing, and excessive weight (due to obesity) against the chest wall, which makes it hard for a person to take a deep breath. As a result, the blood has too much carbon dioxide and not enough oxygen. People with OHS are often tired due to sleep loss, poor sleep quality, and chronic hypoxia.
Excess (morbid) obesity is the main risk factor.
See also: Respiratory acidosis
Symptoms Return to top
The main symptoms of OHS are due to lack of sleep and include:
Symptoms of low blood oxygen level (chronic hypoxia) can also occur, such as shortness of breath or feeling tired after very little effort.
Exams and Tests Return to top
People with OHS are usually very overweight. Symptoms of OHS include:
Tests to confirm OHS include:
Doctors can tell OHS from obstructive sleep apnea by high carbon dioxide levels in the blood when a person is awake.
Treatment Return to top
The treatment involves breathing assistance using special machines (mechanical ventilation). Options include:
Other treatments are aimed at weight loss, which can reverse OHS.
Support Groups Return to top
Support groups can help patients with OHS, or their family members, adjust to the lifestyle changes needed for treatment to be successful. Also, support groups can offer information about new treatments.
Outlook (Prognosis) Return to top
When treated, OHS has a good outcome (prognosis). Untreated, it can lead to serious heart and blood vessel problems, severe disability, or death.
Possible Complications Return to top
Complications of OHS have to do with a lack of sleep, such as:
OHS can also include heart problems, such as:
When to Contact a Medical Professional Return to top
Call your health care provider if you are very tired during the day, or have any other symptoms that suggest OHS.
Prevention Return to top
Maintain a healthy weight and avoid obesity.
References Return to top
Murray J, Nadel J. Textbook of Respiratory Medicine. 3rd ed. Philadelphia, Pa: W.B. Saunders Company; 2000:2326-2328.
Moore DP, Jefferson JW. Handbook of Medical Psychiatry. 2nd ed. St. Louis, Mo: Mosby, Inc; 2004:221-223.Update Date: 8/10/2007 Updated by: Allen J. Blaivas, DO, Pulmonary, Critical Care, and Sleep Medicine, Department of Veteran Affairs, VA System, East Orange, NJ. Review provided by VeriMed Healthcare Network.