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Alternative Names Return to topGonadotropin deficiency; Secondary hypogonadism; Kallmann syndrome
Definition Return to top
Hypogonadotropic hypogonadism is absent or decreased function of the male testes or the female ovaries. It is considered a form of secondary hypogonadism, which means the condition is due to a problem with the pituitary or hypothalamus gland.
See also: Hypogonadism
Causes Return to top
Hypogonadotropic hypogonadism results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Normally, the hypothalamus in the brain releases gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release other hormones, including FSH and LH. These hormones tell the female ovaries and male testes to secrete hormones that are responsible for normal sexual development in puberty. A disruption in this chain of events causes a deficiency of the sex hormones and halts normal sexual maturation.
Failure of the hypothalamus is most commonly a result of Kallmann syndrome. Kallmann syndrome is an inherited form of hypogonadotropic hypogonadism that usually involves a disorder with the sense of smell.
Symptoms Return to top
Exams and Tests Return to top
Tests that may be done include:
Treatment Return to top
Treatment depends on the source of the problem but may involve:
Outlook (Prognosis) Return to top
With proper hormonal stimulation, puberty can occur and fertility may be restored.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
Call your health care provider if your child does not enter puberty as expected.
Prevention Return to top
Prevention depends on the cause. Genetic counseling may be appropriate for individuals with a family history of inherited disorders associated with hypogonadism. Prevention of serious head injuries reduces the risk of pituitary injury-associated hypogonadotropic hypogonadism.
References Return to top
AACE Thyroid Task Force. AACE Hypogonadism Guidelines. Endocr Pract. 2002;8(6):441.Update Date: 10/24/2007 Updated by: Robert Hurd, MD, Professor of Endocrinology, Department of Biology, Xavier University, Cincinnati, OH, and physician in the Primary Care Clinic, Cincinnati Veterans Administration Medical Center, Cincinnati, Ohio. Review provided by VeriMed Healthcare Network.