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Alternative Names Return to topOvalocytosis - hereditary
Definition Return to top
Hereditary ovalocytosis is rare condition passed down through families (inherited) in which blood cells are slightly oval-shaped instead of round. It is a form of hereditary elliptocytosis.
Causes Return to top
Ovalocytosis is mainly found in Southeast Asian populations.
Symptoms Return to top
Newborn infants with ovalocytosis may have anemia and jaundice. Adults usually do not show symptoms and are known as asymptomatic.
Exams and Tests Return to top
An examination by your health care provider may occasionally show an enlarged spleen.
This condition is diagnosed by looking at the shape of blood cells under a microscope. The following tests may also be done:
Treatment Return to top
In severe cases, the disease may be treated by removal of the spleen (splenectomy).
Possible Complications Return to top
The condition may be associated with gallstones or kidney problems.
References Return to top
Jeng MR. Hematologic problems in immigrants from Southeast Asia. Hematol Oncol Clin North Am. Dec 2004;18(6):1405-22, x.
Laosombat V, Dissaneevate S, Wongchanchailert M, Satayasevanaa B. Neonatal anemia associated with Southeast Asian ovalocytosis. Int J Hematol. 2005 Oct;82(3):201-5.Update Date: 11/10/2008 Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.