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Alternative Names Return to topAmyloidosis - secondary systemic
Definition Return to top
Secondary systemic amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid deposits.
Secondary means it occurs because of another disease or situation. For example, this condition usually occurs as a result of chronic infection or chronic inflammatory disease.
Systemic means body-wide. For example, a systemic disease affects the entire body.
Causes Return to top
The exact cause of amyloidosis is unknown. You are more likely to develop secondary systemic amyloidosis if you have a long-term infection or inflammation.
This condition may occur along with:
Symptoms Return to top
Exams and Tests Return to top
Tests that may be done include:
Treatment Return to top
The condition that is causing the amyloidosis should be treated. Some persons may need a bone marrow or stem cell transplant. There is no specific treatment for amyloidosis itself.
Outlook (Prognosis) Return to top
How well a person does depends on which organs are affected. If the disease involves the heart and kidneys, it may lead to organ failure and death.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
Call your health care provider if you have symptoms of this condition. The following are serious symptoms that require prompt medical attention:
Prevention Return to top
If you have a disease that's known to increase your risk of this condition, make sure you get it treated. This may help prevent amyloidosis.
References Return to top
Buxbaum JN. The amyloidoses. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 296.Update Date: 5/3/2009 Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.