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Alternative Names Return to topPneumocystosis; PCP; Pneumocystis jiroveci
Definition Return to top
Pneumocystis carinii pneumonia (PCP) is a fungal infection of the lungs.
Causes Return to top
PCP is a pneumonia caused by the fungal organism Pneumocystis carinii (now renamed Pneumocystis jiroveci). This organism is common in the environment and does not cause illness in healthy people.
However, Pneumocystis carinii can cause a lung infection in in people with a weakened immune system due to any of the following conditions:
PCP was a relatively rare infection before the AIDS epidemic. Before the use of preventive antibiotics for PCP, up to 70% of people in the U.S. with advanced AIDS would develop PCP.
Symptoms Return to top
PCP in those with AIDS usually develops slowly and is less severe. People with PCP who do not have AIDS usually get sick faster and are more acutely ill.
Exams and Tests Return to top
Treatment Return to top
The main treatment for PCP is with drugs that kill the bacteria (antimicrobial therapy). Antibiotics can be given by mouth (orally) or through a vein (intravenous), depending on the severity of the illness.
People with low oxygen levels and moderate to severe PCP often take corticosteroids as well.
Outlook (Prognosis) Return to top
Pneumocystis carinii pneumonia can be life-threatening, and respiratory failure can lead to death. People with this condition need early and effective treatment. For moderate to severe PCP in people with AIDS, the use of corticosteroids has decreased mortality.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
If you have a weakened immune system due to AIDS, cancer, transplantation, or corticosteroid use, call your doctor if you develop a cough, fever, or shortness of breath.
While many infections can lead to similar symptoms, you should have a medical evaluation to rule out opportunistic infections such as PCP.
Prevention Return to top
Preventive therapy is recommended for: