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Alternative Names Return to topMyasthenic syndrome; Eaton-Lambert syndrome
Definition Return to top
Lambert-Eaton syndrome is a disorder in which faulty communication between nerves and muscles leads to muscle weakness .
Causes Return to top
Lambert-Eaton syndrome occurs when nerves cells do not release enough of a chemical called acetylcholine, which transmits impulses between nerves and muscles.
The result is muscle weakness and other symptoms similar to myasthenia gravis. However, as the muscles continue to contract, the chemical (acetylcholine) can build up in sufficient quantities for strength to get slightly better.
Lambert-Eaton syndrome may be associated with cancers such as small-cell lung cancer and autoimmune disorders.
Symptoms Return to top
Additional symptoms that may be associated with this disease:
Exams and Tests Return to top
A physical examination shows weakness or paralysis that gets slightly better with activity. Reflexes may be decreased. There may be loss of muscle tissue.
Tests to help diagnose and confirm the condition may include:
Treatment Return to top
The main goal of treatment is to identify and treat any underlying disorders.
A method called plasmapheresis may improve symptoms. Plasmapheresis involves removing blood plasma from the body and replaced it with fluid, protein, or donated plasma. This helps to make sure that any harmful proteins (antibodies) that are interfering with nerve function are removed from the body.
Medications that suppress the immune response, such as prednisone, may improve symptoms in some cases. Medications may also include:
Outlook (Prognosis) Return to top
The symptoms of Lambert Eaton syndrome may improve with treatment of the underlying disease or by suppressing the immune system. However, not all people respond well to treatment.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
Call your health care provider if symptoms of this condition develop.Update Date: 9/16/2008 Updated by: Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.