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Alternative Names Return to topArkless-Graham; Acrodysplasia; Maroteaux-Malamut
Definition Return to top
Acrodysostosis is an extremely rare disorder that is present at birth (congenital). People with this condition have problems in the bones of the hands, feet, and nose, and mental retardation.
Causes Return to top
Most patients with acrodysostosis have no family history of the disease. However, sometimes the condition is passed down from parent to child. Parents with the condition have a 1 in 2 chance of passing the disorder to their children.
There is a slightly greater risk with fathers who are older.
Symptoms Return to top
Exams and Tests Return to top
A physical exam confirms this disorder.
Findings may include:
In the first months of life, x-rays may show spotty calcium deposits, called stippling, in bones (especially the nose). Infants may also have:
Treatment Return to top
Treatment depends on the physical and mental problems that occur.
Orthopedic care, early intervention, and special education are recommended.
Outlook (Prognosis) Return to top
Problems depend on the degree of skeletal involvement and mental retardation. In general, patients do relatively well.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
Call your health care provider if your child seems to be growing or developing slowly or abnormally, or if you notice physical abnormalities in your infant.
Prevention Return to top
Consider genetic counseling to help with diagnosis, testing, and identifying risk.Update Date: 10/15/2008 Updated by: Diana Chambers, MS, EdD, Certified Genetics Counselor (ABMG), Charter Member of the ABGC, University of Tennessee, Memphis, TN. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.