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Alternative NamesEagle-Barrett syndrome
Definition Return to top
Prune belly syndrome is a group of birth abnormalities marked by three major findings:
Causes Return to top
The underlying causes of prune belly syndrome are unknown. It affects mostly boys.
When in the womb, the developing baby's abdomen swells with fluid. That fluid disappears after birth, leading to a wrinkled abdomen that looks like a prune. The appearance is more noticeable because of the lack of enough abdominal muscles.
Symptoms Return to top
Exams and Tests Return to top
Expectant mothers carrying affected infants may have varying degrees of oligohydramnios (not enough amniotic fluid), which make the infant likely to have lung problems.
An ultrasound done during pregnancy may show that the baby has a swollen bladder or enlarged kidney.
In some cases, a pregnancy ultrasound may also help determine if the baby has:
The following tests may be performed on the baby after birth to diagnose the condition:
Treatment Return to top
Surgery is commonly done to repair genital and bladder problems.
The baby may be given antibiotics to treat or help prevent urinary tract infections.
Outlook (Prognosis) Return to top
Prune belly syndrome is a serious and often life-threatening problem.
Many infants with prune belly syndrome are either stillborn or die within the first few weeks of life from severe lung or kidney problems, or a combination of birth problems.
Some newborns survive with varying degree of recurring problems.
Possible Complications Return to top
Complications depend on the related problems. The most common are chronic kidney failure and club foot.
When to Contact a Medical Professional Return to top
Prune belly syndrome is usually diagnosed before birth or at the time of birth.
If you have a child with diagnosed prune belly syndrome, call your health care provider at the first sign of a urinary tract infection or other urinary symptoms. If, before birth, your baby is seen to have a distended bladder or enlarged kidneys on prenatal ultrasound, seek the advice of a specialist in high-risk pregnancy or perinatology.
Prevention Return to top
There is no known guaranteed prevention. If a prenatal diagnosis of urinary tract obstruction is made, in rare cases surgery performed during the pregnancy may help prevent the problem from progressing to prune belly syndrome.Update Date: 10/11/2007 Updated by: Deirdre O’Reilly, MD, MPH, Neonatologist, Division of Newborn Medicine, Children’s Hospital Boston and Instructor in Pediatrics, Harvard Medical School, Boston, Massachusetts. Review Provided by VeriMed Healthcare Network.