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Alternative Names Return to topHutchinson-Gilford syndrome
Definition Return to top
Progeria is a disease that produces rapid aging, beginning in childhood.
Causes Return to top
Progeria is a rare condition that is remarkable because its symptoms strongly resemble normal human aging, but occur in young children.
Ninety percent of children with progeria have a mutation on the gene that encodes the protein lamin A. Progeria usually occurs without cause. It is not seen in siblings of affected children, although -- in very rare circumstances -- more than one child in a family can have the condition.
Symptoms Return to top
Exams and Tests Return to top
The signs include:
Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.
Genetic testing can detect mutations in lamin A that cause progeria.
Treatment Return to top
There is presently no treatment for progeria.
Support Groups Return to top
Progeria Research Foundation, Inc. -- www.progeriaresearch.org
Outlook (Prognosis) Return to top
Progeria is associated with a short lifespan. The average patient survives to the early teens. However, some patients can live up to 30 years. The cause of death is usually related to the heart or a stroke as a result of the progressive atherosclerosis.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
Call for an appointment with your health care provider if you child does not appear to be growing or developing normally.
Prevention Return to top
There is no known prevention.Update Date: 7/2/2007 Updated by: Brian Kirmse, MD, Mount Sinai School of Medicine, Department of Human Genetics, New York, NY. Review provided by VeriMed Healthcare Network.