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An invasive disease is one that spreads to surrounding tissues. An invasive procedure is one in which the body is "invaded" or entered by a needle, tube, device, or scope.Update Date: 5/2/2009 Updated by: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.