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Definition Return to top
Leucine aminopeptidase is a protein, called an enzyme, that is normally found in liver cells. This article discusses the test to measure how much of this protein appears in your urine.
Your blood can also be checked for this protein. See also: Leucine aminopeptidase - blood
How the Test is Performed Return to top
A 24-hour urine sample is needed.
Label the container with your name, the date, the time of completion, and return it as instructed.
For an infant, thoroughly wash the area where urine exits the body.
This procedure may take a couple of attempts -- lively infants can move the bag, causing the urine to be absorbed by the diaper. Check the infant frequently and change the bag after the infant has urinated into it. Drain the urine from the bag into the container provided by your health care provider.
Deliver it to the laboratory or your health care provider as soon as possible upon completion.
Your health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
How to Prepare for the Test Return to top
Your health care provider may tell you to stop taking any drugs that could affect the test. Drugs that can affect the results of this test include estrogen and progesterone. Never stop taking any medicine without first talking to your doctor.
How the Test Will Feel Return to top
The test involves only normal urination, and there is no discomfort.
Why the Test is Performed Return to top
Your doctor may order this test to see if your liver is damaged. It may also be done to check for certain tumors.
Normal Results Return to top
Normal values range from 2 - 18 units per 24 hours.
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean Return to top
Increased levels of leucine aminopeptidase can be seen in several conditions:
Risks Return to top
There is essentially no risk.
References Return to top
Berk P, Korenblatt K. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.Update Date: 1/28/2009 Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and George F Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.