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Alternative NamesEosinophils; Absolute eosinophil count
Definition Return to top
An absolute eosinophil count is a blood test that measures the number of white blood cells called eosinophils. Eosinophils become active when you have certain allergic diseases, infections, and other medical conditions.
See also: Blood differential
How the Test is Performed Return to top
Blood is drawn from a vein, usually on the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and an elastic band is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the band to fill with blood.
A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore blood flow. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
For an infant or young child, the area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. Cotton or a bandage may be applied to the puncture site if there is any continued bleeding.
In the laboratory, the blood is placed on a microscope slide. A stain added to the sample causes eosinophils to show as orange-red granules. The technician then counts how many eosinophils are present per 100 cells. The percentage of eosinophils is multiplied by the white blood cell count to give the absolute eosinophil count.
How to Prepare for the Test Return to top
No special preparation is necessary for adults.
Certain medicines may cause you to have an increase in eosinophils. Such medicines include:
How the Test Will Feel Return to top
When the needle is inserted to draw blood, some people may feel moderate pain. Others may feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Why the Test is Performed Return to top
Your doctor may order an eosinophil count if the results of another blood test, called a blood differential, are abnormal. This test may also be done if the doctor thinks you may have a specific disease.
This test may help diagnose:
Normal Results Return to top
Less than 350 cells per microliter (cells/mcL).
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean Return to top
High numbers of eosinophils (eosinophilia) are usually associated with allergic diseases and infections from parasites such as worms. A high eosinophil count may be due to:
A lower-than-normal eosinophil count may be due to:
Risks Return to top
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
Considerations Return to top
The eosinophil count usually helps confirm, rather than make, a diagnosis. It can not tell if an increase is caused by allergy or parasite infection.
References Return to top
Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, Pa: Churchill Livingston; 2005:768.
McPherson RA and Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa: WB Saunders; 2007:474.Update Date: 1/12/2009 Updated by: Todd Gersten, M.D., Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.