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Alternative Names Return to topZygomycosis
Definition Return to top
Mucormycosis is a fungal infection of the sinuses, brain, or lungs that occurs primarily in people with immune disorders.
Causes Return to top
Mucormycosis is caused by common fungi frequently found in the soil and in decaying vegetation. Most individuals are exposed to these fungi on a daily basis -- but people with immune disorders may be more susceptible to infection.
Conditions most commonly associated with mucormycosis include diabetes (usually poorly controlled diabetes), chronic steroid use, metabolic acidosis, organ transplantation, leukemia/lymphoma, treatment with deferoxamine, and AIDS.
Syndromes associated with mucormycosis include:
Symptoms Return to top
Symptoms of rhinocerebral mucormycosis include:
Symptoms of lung (pulmonary) mucormycosis include:
Symptoms of gastrointestinal mucormycosis include:
Symptoms of kidney (renal) mucormycosis include:
Symptoms of skin (cutaneous) mucormycosis include a single, painful, hardened area of skin that may have a blackened center.
Exams and Tests Return to top
Mucormycosis should be suspected if symptoms appear in individuals with immune disorders such as diabetes or those with weakened immune systems such as transplant recipients. Symptoms of rhinocerebral mucormycosis are most likely to occur among immunosuppressed people.
Depending on where the symptoms are, CT scans or MRIs may be done. Evaluation by an ear-nose-throat specialist is recommended if sinus involvement is suspected.
A tissue specimen must be taken and analyzed in order to make a definitive diagnosis of mucormycosis.
Treatment Return to top
Mucormycosis is treated right away with surgery to remove all dead and infected tissue, along with intravenous (directly into a vein) antifungal therapy. Surgical removal of infected tissue may be disfiguring because it may involve removal of the palate, parts of the nose, or parts of the eye. Withoutt his aggressive surgery, however, chances of survival are greatly decreased.
Outlook (Prognosis) Return to top
Mucormycosis has an extremely high mortality rate even with aggressive surgical intervention. Death rates range from 25 - 80% depending on the body area involved and the individual's underlying immune problems.
Possible Complications Return to top
When to Contact a Medical Professional Return to top
People with immune disorders (including diabetes) should seek medical attention if they develop fever, headache, sinus pain, eye swelling, or any of the other symptoms listed above.
Prevention Return to top
Because the fungi that cause mucormycosis are widespread, the most appropriate preventive measures involve improved control of the underlying illnesses associated with mucormycosis.
References Return to topStevens DA. Aspergillosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 360. Update Date: 12/3/2008 Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.